Oligodendrocyte formation in the adult brain is associated with glial-restricted progenitor cells, known as oligodendrocyte progenitor cells (OPCs). SVZ cells migrate away from germinal zones to populate both developing white and gray matter, where they differentiate Location: Central nervous system.
Dec 11, · adult oligodendrocyte; remyelination; large animal models; Remyelination is the most effective and robust endogenous repair mechanism of the central nervous system (CNS) and can lead to complete remyelination of large and disseminated areas of demyelination in the CNS, with resultant functional recovery (1, 2).It has been known for some time that remyelination occurs in multiple Cited by: 9.
Oligodendrocyte progenitor cells (OPCs), also known as oligodendrocyte precursor cells, NG2-glia or polydendrocytes, are a subtype of glial cells in the central nervous system. They are precursors to oligodendrocytes and may also be able to differentiate into neurons and astrocytes. Differentiated oligodendrocytes support axons and provide electrical insulation in the form of Location: Central nervous system.
NG2 + cells constitute an abundant population in the adult CNS. Our studies of the rat cerebral cortex indicated that an even distribution of O4 + oligodendrocyte progenitors that did not express proteins or lipids characteristic of mature oligodendrocytes existed in the adult (Reynolds & Hardy, ).We went on to demonstrate that the O4 + cells in the cortical grey matter that were not Cited by: